Pack R J, Al-Ugaily L H, Widdicombe J G
Cell Tissue Res. 1984;238(1):61-8. doi: 10.1007/BF00215145.
In the mouse, nerves were located throughout the trachea and extrapulmonary bronchi in both the smooth muscle and the connective tissue. However, no nerves were found within the epithelium. In the smooth muscle there were large numbers of nonmyelinated nerves. These were usually 'en passant' elements but varicosities containing small mitochondria and vesicles were also seen; these axons sometimes appeared to be efferent to the muscle. Unilateral cervical vagotomy reduced the numbers of nerves in the muscle of the trachea and ipsilateral primary bronchus, suggesting that they were afferent. The intramuscular nerves were characterized in terms of their complement of cytoplasmic organelles; in particular nerves containing many mitochondria disappeared following vagotomy. Pretreatment of mice with 5-hydroxydopamine to accentuate the electron-opacity of catecholamine-containing granules resulted in 3.5% of the nerves within tracheal muscle showing such granules. The afferent nerves of the smooth muscle may be complex branching structures with many varicosities. The absence of epithelial nerves may be related to the absence of the cough reflex in the mouse.
在小鼠中，神经分布于气管和肺外支气管的平滑肌和结缔组织中。然而，上皮内未发现神经。平滑肌中有大量无髓神经。这些通常是“串珠样”结构，但也可见含有小线粒体和囊泡的膨体；这些轴突有时似乎是向肌肉传出的。单侧颈迷走神经切断术减少了气管和同侧主支气管肌肉中的神经数量，表明它们是传入神经。肌内神经根据其胞质细胞器的组成进行表征；特别是，含有许多线粒体的神经在迷走神经切断术后消失。用5-羟多巴胺预处理小鼠以增强含儿茶酚胺颗粒的电子不透明度，结果气管肌肉内3.5%的神经显示有此类颗粒。平滑肌的传入神经可能是具有许多膨体的复杂分支结构。上皮神经的缺失可能与小鼠咳嗽反射的缺失有关。
