Marklund S L, Hägglöf B
Clin Chim Acta. 1984 Oct 15;142(3):299-305. doi: 10.1016/0009-8981(84)90266-3.
Toxic oxygen-centered radicals have been linked to beta-cell damage brought about by some chemicals and might conceivably also be of importance in the pathogenesis of spontaneous insulin-dependent diabetes mellitus (IDDM). In several model systems, superoxide dismutase has been protective. The major protector against superoxide radicals in the extracellular space appears to be a recently discovered superoxide dismutase, EC-superoxide dismutase. This enzyme was analysed in plasma from children with insulin-dependent diabetes mellitus. The specimens were obtained from 8 patients with disease of recent onset and from 15 patients with disease of longer duration. There was no significant difference in EC-superoxide dismutase between the patients and controls.
以氧为中心的毒性自由基与某些化学物质导致的β细胞损伤有关，并且可以想象在自发性胰岛素依赖型糖尿病（IDDM）的发病机制中也具有重要意义。在几个模型系统中，超氧化物歧化酶具有保护作用。细胞外空间中超氧化物自由基的主要保护剂似乎是最近发现的一种超氧化物歧化酶，即胞外超氧化物歧化酶（EC-超氧化物歧化酶）。对胰岛素依赖型糖尿病儿童的血浆中的这种酶进行了分析。样本取自8例近期发病的患者和15例病程较长的患者。患者与对照组之间的EC-超氧化物歧化酶没有显著差异。
