Yli-Kerttula U I
Clin Rheumatol. 1984 Sep;3(3):351-60. doi: 10.1007/BF02032342.
To investigate the clinical characteristics of Reiter's syndrome (RS) or uro-arthritis in females, 73 consecutive patients were studied. The findings were compared to those in 72 consecutive males with RS. The mean ages and the clinical picture of musculoskeletal findings, including frequency of mono- or oligoarthritis (68-69%), polyarthritis (26%) and back complaints (76-71%), were similar in both sexes. Inflammation of the knee, sterno-clavicular joint and "sausage" toe occurred predominantly in males and finger involvements in females. Anamnestic gonorrhoea occurred in 17 males (24%) and in 9 females (12%) (p less than 0.05) and verified aseptic pyuria in 34 males (47%) and in 19 females (26%) (p less than 0.01). Clinical findings of urogenital abnormalities (61 and 51%) and evidence of chlamydial infection (61 and 58%) occurred equally frequently in both sexes, as did the less commonly observed gastrointestinal involvements as triggering infection. The males had high ESR (greater than or equal to 50 mm/h) and HLA-B27 antigen more often than females (p less than 0.005 and p less than 0.025 respectively). Pyuria and elevated ESR (greater than or equal to 20 mm/h) were associated with HLA-B27 in males (p less than 0.02) but not in females. The occurrence of sacroiliitis was not associated with HLA-B27 and was not sex-related. The many similarities in the clinical picture speak in favour of the same disease in both sexes. Though the "complete" form of RS with high ESR seems to be more rare in females than in males, the results of the present study emphasize that uro-arthritis is not a rare disease in females as compared to males.
为研究女性赖特综合征（RS）或泌尿关节炎的临床特征，对73例连续病例进行了研究。将研究结果与72例连续的男性RS患者进行比较。男女两性的平均年龄以及肌肉骨骼检查结果的临床表现相似，包括单关节炎或寡关节炎（68 - 69%）、多关节炎（26%）和背部疼痛（76 - 71%）的发生率。膝关节、胸锁关节和“腊肠样”趾的炎症主要见于男性，而手指受累多见于女性。既往有淋病病史的男性有17例（24%），女性有9例（12%）（p < 0.05），经证实有无菌性脓尿的男性有34例（47%），女性有19例（26%）（p < 0.01）。泌尿生殖系统异常的临床表现（61%和51%）以及衣原体感染的证据（61%和58%）在男女两性中出现的频率相同，作为触发感染的较少见的胃肠道受累情况也是如此。男性的血沉（ESR）较高（≥50 mm/h）且HLA - B27抗原阳性率高于女性（分别为p < 0.005和p < 0.025）。脓尿和血沉升高（≥20 mm/h）在男性中与HLA - B27相关（p < 0.02），而在女性中则无此关联。骶髂关节炎的发生与HLA - B27无关，也无性别差异。临床表现的诸多相似之处表明男女两性患的是同一种疾病。尽管血沉高的“完全型”RS在女性中似乎比男性更少见，但本研究结果强调，与男性相比，泌尿关节炎在女性中并非罕见疾病。
