Thune P, Eeg-Larsen T
Contact Dermatitis. 1984 Aug;11(2):98-107. doi: 10.1111/j.1600-0536.1984.tb00935.x.
The patient group consisted of 18 elderly male patients with persistent light reactivity who were subjected to extensive phototesting with different wavelengths, including patch and photopatch testing. All reacted adversely to ultraviolet light and some also to longer wavelengths when tested on normal appearing skin. 17 patients showed contact or photocontact reactions, of which 12 were positive photopatch test reactions and 11 were plain contact reactions. Contact allergy to constituents of oak moss and different lichen compounds was twice as common as allergy to Compositae oleoresins. 72 patients with chronic polymorphic light eruption were used as a control group. 10 of these patients had either a positive photopatch test reaction or a plain contact allergy. Patients with persistent light reactivity are characterized by a particular susceptibility to develop a delayed-type hypersensitivity. They frequently have both photo and plain contact allergy, often to substances used in cosmetics. In 13 of 16 patients in whom a biopsy was carried out, the histology supported the clinical diagnosis. In none of the biopsies was the picture diagnostic in itself. This underlines the inadequacy of light microscopy as the only diagnostic procedure.
患者组由18名有持续光反应性的老年男性患者组成，他们接受了包括斑贴试验和光斑贴试验在内的不同波长的广泛光测试。在外观正常的皮肤上进行测试时，所有患者对紫外线均有不良反应，部分患者对较长波长的光也有反应。17名患者出现接触或光接触反应，其中12例为阳性光斑贴试验反应，11例为单纯接触反应。对橡苔成分和不同地衣化合物的接触性过敏是对菊科植物树脂过敏的两倍。72例慢性多形性日光疹患者作为对照组。其中10例患者有阳性光斑贴试验反应或单纯接触性过敏。有持续光反应性的患者的特点是特别容易发生迟发型超敏反应。他们经常同时有光过敏和单纯接触性过敏，且常常对化妆品中使用的物质过敏。在16例进行活检的患者中，有13例的组织学检查支持临床诊断。在所有活检中，仅凭图像本身均无法确诊。这突出了仅用光镜检查作为唯一诊断方法的不足之处。
