Málek I, Oppelt A, Nestával A, Kidéry J, Jedlicka J, Stanĕk V
Cor Vasa. 1984;26(4):248-56.
The acute effect of nifedipine (Adalat, Bayer) was evaluated in 54 men with a history of transmural myocardial infarction. Haemodynamic changes (in 20 patients) and/or changes in left ventricular radionuclide ejection fraction (LVREF) (41 patients) were studied. 20 to 30 min after sublingual administration of 1 Adalat capsule (10 mg nifedipine) a decrease in arterial pressure and systemic resistance, and an increase in heart rate and cardiac output were observed already at rest. During exercise (50 W) there moreover occurred a decrease in pulmonary artery pressure and in arterial oxygen tension. LVREF was pathologically reduced already at rest, and in most patients exercise led to its further decrease. LVEF increased after Adalat administration only during exercise. In men with a history of myocardial infarction without clinical manifestations of heart failure, Adalat acted predominantly as a peripheral vasodilator; a negative inotropic effect was not demonstrable. The decrease in arterial oxygen tension, observed during exercise, was not clinically important.
对54例有透壁性心肌梗死病史的男性患者评估了硝苯地平（拜耳公司的心痛定）的急性效应。研究了血流动力学变化（20例患者）和/或左心室放射性核素射血分数（LVREF）的变化（41例患者）。舌下含服1粒心痛定胶囊（10mg硝苯地平）后20至30分钟，静息时即观察到动脉压和全身阻力降低，心率和心输出量增加。运动期间（50W），肺动脉压和动脉血氧张力也出现降低。LVREF静息时即已病理性降低，大多数患者运动后进一步降低。仅在运动期间，服用心痛定后LVEF增加。在无心力衰竭临床表现的心肌梗死病史男性患者中，心痛定主要起外周血管扩张剂的作用；未显示出负性肌力作用。运动期间观察到的动脉血氧张力降低在临床上并不重要。
