丁苯那嗪（Nitoman）治疗慢性自发性口腔运动障碍。一项视频和肌电图控制的研究。

Tetrabenazine (Nitoman) therapy of chronic spontaneous oral dyskinesia. A video- and EMG-controlled study.

作者信息

Bartels M, Zeller E

出版信息

Eur Arch Psychiatry Neurol Sci. 1984;234(3):172-4. doi: 10.1007/BF00461557.

Abstract

Therapeutic results achieved with tetrabenazine in six patients with spontaneous oral dyskinesia were evaluated by clinical rating as well as time-blind video and EMG assessment. Dramatic improvement of symptoms was observed in five of our six patients and good to satisfactory improvement in the remaining patient. The correspondence among clinical findings, EMG data, and video analysis was good. Medication was started at low doses and slowly increased. Adverse reactions (i.e., rigidity, akinesia, vasodepression) were minimal.

摘要

采用临床评分以及非同期录像和肌电图评估，对6例自发性口腔运动障碍患者使用丁苯那嗪的治疗效果进行了评估。6例患者中有5例症状显著改善，其余1例改善良好至令人满意。临床发现、肌电图数据和视频分析之间的一致性良好。用药从小剂量开始，然后缓慢增加。不良反应（如强直、运动不能、血管抑制）极少。