牛磺酸对豚鼠心室肌条的变力作用。
Inotropic effect of taurine in guinea-pig ventricular strips.
作者信息
Franconi F, Stendardi I, Matucci R, Failli P, Bennardini F, Antonini G, Giotti A
出版信息
Eur J Pharmacol. 1984 Jul 20;102(3-4):511-4. doi: 10.1016/0014-2999(84)90572-7.
At 0.9 mM CaCl2 taurine prevented the negative inotropic effect due to low calcium concentration in guinea-pig ventricular strips but not in rat strips. This taurine effect was dose-dependent. The presence (in the perfusion medium) of beta-alanine, an inhibitor of taurine transport, antagonized the effect of taurine suggesting that the action of taurine was correlated to its transport. Neither propranolol, cimetidine nor indomethacin affected the response to taurine in guinea-pig ventricular strips.
在0.9 mM氯化钙浓度下，牛磺酸可防止豚鼠心室肌条因低钙浓度引起的负性肌力作用，但对大鼠肌条无效。这种牛磺酸效应具有剂量依赖性。牛磺酸转运抑制剂β-丙氨酸（存在于灌注培养基中）可拮抗牛磺酸的作用，这表明牛磺酸的作用与其转运相关。普萘洛尔、西咪替丁和吲哚美辛均不影响豚鼠心室肌条对牛磺酸的反应。
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