牛磺酸对豚鼠心室肌条钙水平及收缩性的影响。
Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips.
作者信息
Franconi F, Martini F, Stendardi I, Matucci R, Zilletti L, Giotti A
出版信息
Biochem Pharmacol. 1982 Oct 15;31(20):3181-5. doi: 10.1016/0006-2952(82)90547-0.
Taurine increases the calcium levels in guinea-pig ventricular strips at external calcium concentrations of 0.45, 0.9 and 1.8 mM. At 2.7 mM calcium, however, a decrease is observed. Analogous changes occur in contractile force. It is also seen that the superfusion of ventricular strips with taurine-free medium produces a decrease in taurine content at the end of 120 min superfusion. Taurine levels can be restored by superfusion with 10 mM taurine; a linear relationship exists between external taurine and internal taurine levels.
在细胞外钙浓度为0.45、0.9和1.8 mM时，牛磺酸可提高豚鼠心室肌条中的钙水平。然而，在钙浓度为2.7 mM时，却观察到钙水平下降。收缩力也出现类似变化。还发现，用无牛磺酸的培养基对心室肌条进行120分钟的灌流后，牛磺酸含量会降低。用10 mM牛磺酸进行灌流可恢复牛磺酸水平；细胞外牛磺酸水平与细胞内牛磺酸水平之间存在线性关系。
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