Tenniswood M, Abrahams P, Bird C, Clark A
Mol Cell Endocrinol. 1984 Sep;37(2):153-8. doi: 10.1016/0303-7207(84)90047-9.
When administered to intact adult male rats, cyproterone acetate (10 mg/day), flutamide (15 mg/day), or Compound I (1 mg/day) caused a significant decrease in the organ weight to body weight ratios, with a concomitant rise in the specific activity of prostatic acid phosphatase. These compounds do not affect two other markers of androgen activity in the prostate. Neither the percentage inhibition of acid phosphatase activity by tartrate nor the appearance of the secretory band of acid phosphatase on polyacrylamide gels was altered by the administration of anti-androgens. When administered to castrated rats given doses of 5 alpha-dihydrotestosterone (250-750 micrograms/day), flutamide (15 mg/day) was unable to alter the percentage inhibition of acid phosphatase activity by tartrate, or the pattern of activity on polyacrylamide gels. These results suggest that these anti-androgens affect only some of the androgen-dependent functions of the prostate.
给成年雄性大鼠完整机体施用醋酸环丙孕酮（10毫克/天）、氟他胺（15毫克/天）或化合物I（1毫克/天）后，前列腺重量与体重之比显著降低，同时前列腺酸性磷酸酶的比活性升高。这些化合物不影响前列腺中雄激素活性的其他两个标志物。施用抗雄激素药物后，酒石酸盐对酸性磷酸酶活性的抑制百分比以及聚丙烯酰胺凝胶上酸性磷酸酶分泌带的出现均未改变。给去势大鼠施用5α-二氢睾酮（250 - 750微克/天）后，再施用氟他胺（15毫克/天），无法改变酒石酸盐对酸性磷酸酶活性的抑制百分比，也无法改变聚丙烯酰胺凝胶上的活性模式。这些结果表明，这些抗雄激素药物仅影响前列腺中某些雄激素依赖性功能。
