Carpentiere G, Marino S, Castello F, Castello A, Cellura M
G Ital Cardiol. 1984 Jul;14(7):530-3.
Thirty patients with essential hypertension, whose blood pressure was controlled by metoprolol, were divided according to age in two groups. All the patients were treated with long-acting metoprolol given as simple daily dose at 08.00 h. Blood pressure and heart rate were recorded before and at the 7th, 15th, 30th, 45th, 60th days of treatment. No significant difference in the antihypertensive effects of metoprolol was detected between the two groups of patients. A significantly higher reduction of the heart rate was observed in the older patients.
30例原发性高血压患者,其血压由美托洛尔控制,根据年龄分为两组。所有患者均在上午8点接受长效美托洛尔治疗,每日一次简单剂量。在治疗前以及治疗的第7天、15天、30天、45天、60天记录血压和心率。两组患者美托洛尔的降压效果未检测到显著差异。老年患者心率下降更为显著。