Assaykeen T A, Michell G
Med J Aust. 1982 Jan 23;1(2):73-7.
We studied the efficacy and tolerability of metoprolol, administered alone or in combination therapy, in 703 hypertensive patients. We observed a significant decrease in both systolic and diastolic blood pressure in patients treated with metoprolol alone or with metoprolol and a diuretic. Of these, 60% to 85% achieved a diastolic blood pressure of 12 kPa (90 mmHg) or lower during the 12-week trial. The maximum effect occurred after approximately three weeks. In the majority of patients, 100 mg twice a day controlled mild to moderate hypertension. Side effects (mainly gastrointestinal disturbances and dizziness) occurred in 15% of patients receiving metoprolol alone and led to treatment withdrawal in 6.7%. For the total patients population, these frequencies were 13.5% and 6.7% respectively, and decreased with time. Asthmatics and diabetics tolerated metoprolol extremely well, indicating the clinical importance of metoprolol's cardioselectivity.
我们研究了美托洛尔单独使用或联合治疗703例高血压患者的疗效和耐受性。我们观察到，单独使用美托洛尔或美托洛尔与利尿剂联合治疗的患者，其收缩压和舒张压均显著降低。其中，60%至85%的患者在12周试验期间舒张压降至12 kPa（90 mmHg）或更低。最大疗效出现在大约三周后。在大多数患者中，每日两次服用100 mg可控制轻至中度高血压。单独接受美托洛尔治疗的患者中，15%出现副作用（主要是胃肠道不适和头晕），6.7%的患者因此停药。在全部患者中，这些发生率分别为13.5%和6.7%，且随时间推移而降低。哮喘患者和糖尿病患者对美托洛尔耐受性极佳，这表明美托洛尔心脏选择性的临床重要性。
