Tanaka M, Kojima H, Akashi A
Nihon Yakurigaku Zasshi. 1984 Aug;84(2):213-9.
This investigation was undertaken to analyze the EEG synchronizing effects of timiperone in cats. The effects of timiperone on the brain-stem reticular and hypothalamic activating system, diffuse and specific thalamic projection system, and caudate spindle were investigated by the electroencephalographic method. Timiperone produced a weak inhibition of EEG arousal response induced by electrical stimulation of the sciatic nerve almost without affecting that which was induced by stimulation of the mesencephalic reticular formation. Furthermore, timiperone suppressed the activation of neocortical EEG in response to stimulation of the posterior hypothalamus more selectively than that of limbic EEG. Neither the recruiting response to stimulation of the centro-median nucleus of the thalamus nor the augmenting response to stimulation of the ventro-postero-lateral nucleus of the thalamus was modified by timiperone. In addition, timiperone significantly potentiated the caudate spindle. The EEG effects of haloperidol were qualitatively similar to those of timiperone. These results indicate that the synchronizing effect of timiperone may be mediated by a suppression of an ascending reticular activating system and may influence the conscious levels and sleep-wakefulness cycle in cats.
本研究旨在分析替米哌隆对猫脑电同步的影响。采用脑电图方法研究了替米哌隆对脑干网状结构和下丘脑激活系统、弥散性和特异性丘脑投射系统以及尾状核纺锤波的影响。替米哌隆对坐骨神经电刺激诱发的脑电觉醒反应产生微弱抑制，几乎不影响中脑网状结构刺激诱发的反应。此外，替米哌隆比边缘脑电更具选择性地抑制下丘脑后部刺激引起的新皮质脑电激活。替米哌隆对丘脑中央中核刺激的募集反应和丘脑腹后外侧核刺激的增强反应均无改变。此外，替米哌隆显著增强了尾状核纺锤波。氟哌啶醇的脑电效应在性质上与替米哌隆相似。这些结果表明，替米哌隆的同步效应可能通过抑制上行网状激活系统介导，并可能影响猫的意识水平和睡眠-觉醒周期。
