Vaishwanar I, Mallik S
Indian J Physiol Pharmacol. 1984 Jan-Mar;28(1):35-41.
The effect of malathion, an organophosphorus insecticide on tissue levels of acetylcholinesterase (Ache), phosphomonoesterases and transaminases have been studied in presence of different levels of dietary proteins. Adult male albino rats weighing 150-200 gms were given 5%, 10% and 20% protein diets containing 400 mg malathion (dust) 5% conc./kg feed for 30 days. Its effect was evaluated in liver, kidney, brain, lungs and spleen and results were compared with their respective malathion dust, pair-fed animals (5%, 10% and 20% protein groups without malathion). Animals kept on low protein diets (5% and 10%) when exposed to malathion dust showed significant increase in the activities of GOT and alkaline phosphatase in liver, kidney, brain, lungs and spleen, while a marked inhibition in the activity of Ache was observed under similar treatment. GPT was decreased in kidney and lungs, in the low protein groups (5% and 10%, whereas its activity was increased in liver, brain and spleen of animals receiving 5% protein, when exposed to compared to their respective pair-fed animals. Thus, although the degree of alteration in the enzyme profile is less severe, these changes show that high protein diet has a protective role against pesticide hazards, whereas low protein diet provides less stability to the structural integrity of the tissues.
在不同水平的膳食蛋白质存在的情况下，研究了有机磷杀虫剂马拉硫磷对乙酰胆碱酯酶（AChE）、磷酸单酯酶和转氨酶组织水平的影响。给体重150 - 200克的成年雄性白化大鼠喂食含有400毫克马拉硫磷（粉剂，5%浓度/千克饲料）的5%、10%和20%蛋白质饲料，持续30天。在肝脏、肾脏、大脑、肺和脾脏中评估其效果，并将结果与各自的马拉硫磷粉剂、配对喂养动物（不含马拉硫磷的5%、10%和20%蛋白质组）进行比较。当暴露于马拉硫磷粉剂时，低蛋白饮食（5%和10%）的动物在肝脏、肾脏、大脑、肺和脾脏中GOT和碱性磷酸酶的活性显著增加，而在类似处理下观察到AChE活性明显受到抑制。低蛋白组（5%和10%）的肾脏和肺中GPT降低，而与各自的配对喂养动物相比，接受5%蛋白质的动物在暴露于马拉硫磷时，其肝脏、大脑和脾脏中的GPT活性增加。因此，尽管酶谱变化的程度不太严重，但这些变化表明高蛋白饮食对农药危害具有保护作用，而低蛋白饮食对组织的结构完整性提供的稳定性较低。
