Eadsforth C V, Logan C J, Morrison B J, Warburton P A
Int Arch Occup Environ Health. 1984;54(3):223-32. doi: 10.1007/BF00379051.
Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. Experiments using rats dosed by the oral route as a model system show that measurement of methaemoglobin content provides a very rapid and simple monitoring method, but is not very sensitive. Measurement of the ortho-hydroxy metabolites of the two compounds, as their benzoxazole derivatives, provides a much more sensitive, but complicated technique. Details of both methods are presented.
已对监测2,4-二氟苯胺和4-氟苯胺暴露的两种可能方法进行了研究：测量血液中的高铁血红蛋白含量和测量尿液代谢物。以经口给药的大鼠作为模型系统进行的实验表明，测量高铁血红蛋白含量提供了一种非常快速且简单的监测方法，但灵敏度不高。测量这两种化合物的邻羟基代谢物（作为它们的苯并恶唑衍生物）提供了一种更为灵敏但复杂的技术。两种方法的详细信息均已给出。
