Wink K
Int J Clin Pharmacol Ther Toxicol. 1984 Aug;22(8):477-50.
After administration of mepindolol, a reduction of the portal pressure was demonstrated in an acute study in six patients with varying degrees of cirrhosis of the liver and in a chronic study in 5 patients. The reduction of the portal pressure did not correlate very closely with the decrease in the cardiac output. It is therefore assumed that a beta 2-receptor effect with dilatation of the splanchnic vessels is the main mechanism. However, further studies are required to clarify the situation unequivocally. The properties of mepindolol (intrinsic sympathomimetic activity, slight negatively inotropic effect, non-selective action, primarily renal elimination) appear to be advantageous in this respect.
在对6例不同程度肝硬化患者进行的急性研究以及对5例患者进行的慢性研究中，给予美吡洛尔后均显示门静脉压力降低。门静脉压力的降低与心输出量的减少并非密切相关。因此推测主要机制是β2受体效应使内脏血管扩张。然而，需要进一步研究以明确阐明这种情况。美吡洛尔的特性（内在拟交感活性、轻微负性肌力作用、非选择性作用、主要经肾排泄）在这方面似乎具有优势。
