Greene S L, Thomas J R, Doyle J A
Int J Dermatol. 1984 Sep;23(7):466-7. doi: 10.1111/ijd.1984.23.7.466.
Cowden's disease (multiple hamartoma syndrome), a rare genodermatosis, is inherited in an autosomal-dominant genetic pattern. It is characterized by mesodermal and epithelial hamartomas appearing as verrucous papules occurring predominantly over the central portion of the face, with perioral and acral papular lesions and papillomatosis of the lips, gingiva, and tongue extending through the entire length of the gastrointestinal tract. These skin lesions have been found to be associated with a number of benign and malignant tumors involving the breast, thyroid, skin, ovaries, adipose tissue, and gastrointestinal tract. The authors report the second case of Cowden's disease associated with malignant melanoma and emphasize the need for a high index of suspicion for related benign or malignant tumors in these cases.
考登病（多发性错构瘤综合征）是一种罕见的遗传性皮肤病，呈常染色体显性遗传模式。其特征为中胚层和上皮错构瘤，表现为疣状丘疹，主要出现在面部中央，伴有口周和肢端丘疹性病变，以及嘴唇、牙龈和舌头的乳头瘤病，并延伸至整个胃肠道。已发现这些皮肤病变与多种涉及乳腺、甲状腺、皮肤、卵巢、脂肪组织和胃肠道的良性及恶性肿瘤有关。作者报告了第二例与恶性黑色素瘤相关的考登病病例，并强调在这些病例中对相关良性或恶性肿瘤要有高度的怀疑指数。
