Rich T A, Cady B, McDermott W V, Kase K R, Chaffey J T, Hellman S
Int J Radiat Oncol Biol Phys. 1984 Oct;10(10):1957-65. doi: 10.1016/0360-3016(84)90278-5.
A 300 kvp orthovoltage machine has been permanently installed in an operating room for delivering intraoperative radiation therapy (IORT). A historical review of orthovoltage IORT and our present approach are described. The preliminary experience with 38 patients treated with orthovoltage IORT indicates that this technique is feasible, has low acute morbidity, and can be useful for palliation. "Radical" radiation therapy consisting of IORT "boost" treatment combined with external beam was used in 24 patients with primary or recurrent cancer. Local failure in 27 patients treated with IORT +/- external beam radiation therapy was 56%, but varied from 11% (1/9) for patients with resected disease to 78% (14/18) for patients with unresected disease. Complications occurred in nine patients (24%) and have been acceptable. There are 17 patients alive and six are NED, with follow-up of 4-18 months. There appears to be a role for orthovoltage IORT especially when combined with surgical resection for local control of advanced cancer arising in the abdomen where the use of high doses of external radiation therapy are hazardous.
一台300千伏峰值的正电压机器已永久安装在手术室中，用于术中放射治疗（IORT）。本文描述了正电压IORT的历史回顾以及我们目前的治疗方法。对38例接受正电压IORT治疗的患者的初步经验表明，该技术是可行的，急性发病率低，可用于姑息治疗。24例原发性或复发性癌症患者采用了由IORT“加强”治疗联合外照射组成的“根治性”放射治疗。27例接受IORT +/- 外照射放疗的患者局部失败率为56%，但从切除疾病患者的11%（1/9）到未切除疾病患者的78%（14/18）不等。9例患者（24%）出现并发症，且并发症情况可接受。有17例患者存活，6例无疾病证据，随访时间为4至18个月。正电压IORT似乎有一定作用，特别是与手术切除联合用于局部控制腹部发生的晚期癌症时，此时使用高剂量外照射放疗存在风险。
