Parsons J T, Cassisi N J, Million R R
Int J Radiat Oncol Biol Phys. 1984 Nov;10(11):2041-51. doi: 10.1016/0360-3016(84)90201-3.
The results of twice-a-day irradiation for moderately advanced and advanced squamous cell carcinomas of the head and neck in 57 patients, treated at the University of Florida between March 1978 and July 1981, are reviewed. Fifty patients received irradiation alone to the primary site with or without neck dissection; 7 patients received preoperative irradiation (5040-6000 rad) followed in 4-6 weeks by resection of the primary tumor and neck dissection(s). Two 120 rad treatments were administered daily, with a 4-6 hour interval between fractions. External beam tumor doses were usually 7440-7680 rad when irradiation alone was used for the primary lesion; 2 of 3 T2 and 11 of 13 (85%) T3 lesions that received greater than or equal to 7440 rad remain locally controlled at 2-5 years' follow-up. External beam doses of 7440 rad controlled only 1 of 10 T4 cancers; higher doses controlled 3 of 8 T4 lesions. One severe complication of irradiation and 2 severe complications of salvage surgery have occurred in the group that received irradiation alone to the primary lesion. Five of the 7 patients who received planned combined preoperative irradiation plus surgery to the primary tumor were alive and free of disease at 2 years. Absolute disease-free survival at 2 years for the entire patient group was 23/57 (40%).
回顾了1978年3月至1981年7月在佛罗里达大学接受治疗的57例中晚期和晚期头颈部鳞状细胞癌患者每日两次照射的结果。50例患者仅对原发部位进行照射，伴或不伴颈部清扫术；7例患者接受术前照射（5040 - 6000拉德），4 - 6周后切除原发肿瘤并进行颈部清扫术。每天给予两次120拉德的治疗，两次照射之间间隔4 - 6小时。当仅对原发病变进行照射时，外照射肿瘤剂量通常为7440 - 7680拉德；接受大于或等于7440拉德照射的3例T2病变中的2例以及13例T3病变中的11例（85%）在2 - 5年的随访中仍保持局部控制。7440拉德的外照射剂量仅控制了10例T4癌症中的1例；更高剂量控制了8例T4病变中的3例。在仅对原发病变进行照射的组中发生了1例严重放疗并发症和2例挽救性手术的严重并发症。接受计划的术前联合照射加手术治疗原发肿瘤的7例患者中有5例在2年时存活且无疾病。整个患者组2年时的绝对无病生存率为23/57（40%）。
