Moorthy C R, Hahn E W, Kim J H, Feingold S M, Alfieri A A, Hilaris B S
Int J Radiat Oncol Biol Phys. 1984 Nov;10(11):2145-8. doi: 10.1016/0360-3016(84)90215-3.
Removable Iridium-192 implants provided a dose of 10 Gy/day or 41.5 cGy/hr at 0.5 cm from the center of 1.0 cm diameter tumors. The total radiation (x) alone was 20, 40 or 60 Gy, representing 2, 4, or 6 days of continuous radiation. The doses used for the combined treatments at elevated temperatures were 10, 20 or 30 Gy. The local tumor hyperthermia (LTH) treatment (43.6 for 35 min, water bath) was administered once for each 10 Gy of dose. The combined radiation + LTH was clearly superior to that achieved with radiation or LTH alone and yielded Thermal Enhancement Ratios (TER) of 3.4-3.9. Local tumor control rate was 67% and 89% for the 20 and 30 Gy x + LTH groups, respectively. A comparison of the results obtained in this study with those of earlier studies on the same tumor system indicate that the effects of Iridium-192 alone on this rapidly proliferating tumor were comparable to similar total doses of fractionated external beam radiation. Iridium + LTH produced a tumor response comparable to that achieved with external fractionated radiation + LTH. Combined treatment effect of elevated temperature appears to be less dose rate dependent in the range of 40 cGy/hr to 100 cGy/min and more dependent upon total dose accumulation.
可移除的铱 - 192植入物在距直径1.0厘米肿瘤中心0.5厘米处提供的剂量为每天10 Gy或每小时41.5 cGy。单独的总辐射量（x）为20、40或60 Gy，分别代表2、4或6天的连续辐射。在高温下联合治疗所使用的剂量为10、20或30 Gy。局部肿瘤热疗（LTH）治疗（43.6℃，持续35分钟，水浴）每10 Gy剂量进行一次。联合放疗 + LTH明显优于单独放疗或LTH，热增强比（TER）为3.4 - 3.9。20 Gy x + LTH组和30 Gy x + LTH组的局部肿瘤控制率分别为67%和89%。将本研究结果与早期关于同一肿瘤系统的研究结果进行比较表明，单独使用铱 - 192对这种快速增殖肿瘤的影响与相同总剂量的分次外照射相当。铱 + LTH产生的肿瘤反应与分次外照射 + LTH相当。在40 cGy/小时至100 cGy/分钟范围内，高温联合治疗效果似乎对剂量率的依赖性较小，而更多地依赖于总剂量积累。
