Alfieri A A, Hahn E W, Kim J H, Lehman D
Radiology. 1978 Oct;129(1):225-7. doi: 10.1148/129.1.225.
The tumoricidal activities of single dose x-irradiation (RAD) and concomitant Actinomycin D (AMD) with or without local tumor hyperthermia (LTH) on an in vivo Methylcholanthreme-induced fibrosarcoma (Meth-A) are described. The addition of LTH enhanced the actions of AMD, RAD and AMD + RAD; the trimodality treatment was most effective. Based on delay of tumor growth, the radiation dose reduction factors for AMD + RAD + LTH compared to RAD; AMD + RAD + LTH, were approximately 2.8, 2.1, and 1.8, respectively. The shape of the curves suggests a further decrease in the ability of the tumor cell to repair sublethal damage with AMD + RAD + LTH. The clinical relevance is not determined.
描述了单剂量X射线照射（RAD）以及联合使用放线菌素D（AMD）并伴有或不伴有局部肿瘤热疗（LTH）对体内甲基胆蒽诱导的纤维肉瘤（Meth-A）的杀肿瘤活性。LTH的加入增强了AMD、RAD和AMD+RAD的作用；三联疗法最为有效。基于肿瘤生长延迟，与RAD相比，AMD+RAD+LTH的辐射剂量降低系数分别约为2.8、2.1和1.8。曲线形状表明，AMD+RAD+LTH使肿瘤细胞修复亚致死损伤的能力进一步降低。其临床相关性尚未确定。
