Burke J A, Chang F W, Potter D E
J Auton Pharmacol. 1984 Sep;4(3):185-92. doi: 10.1111/j.1474-8673.1984.tb00095.x.
Aminotetralin compounds, A-6, 7-DTN and TL-99, produced bisphasic changes in intraocular pressure (IOP) and pupillary dilatation in rabbits. The rise in IOP appeared to result from an action on extraocular muscles because this effect was not produced by either compound in rabbits with transected extraocular muscles. The ocular hypotensive action of A-6, 7-DTN and TL-99 was markedly attenuated in sympathectomized rabbits indicating that this action resulted from suppression of sympathetic neuronal activity. Inhibition of ocular hypertension induced by waterloading by both compounds and suppression of the IOP recovery rate by A-6, 7-DTN suggested that the latter compound lowered IOP, in part, by inhibiting aqueous humor formation. The ocular hypotensive action of A-6, 7-DTN was antagonized by pretreatment with sulpiride, but not by yohimbine, indicating that dopamine receptors are involved in the response. These studies demonstrated that dopamine agonists can lower IOP and suggest that these types of drugs might prove useful in the therapy of open-angle glaucoma.
氨基四氢萘化合物A - 6、7 - DTN和TL - 99可使兔眼压（IOP）和瞳孔散大出现双相变化。眼压升高似乎是由于对眼外肌的作用所致，因为在眼外肌横断的兔中，这两种化合物均未产生此效应。在去交感神经的兔中，A - 6、7 - DTN和TL - 99的眼降压作用明显减弱，表明该作用是由交感神经神经元活动的抑制引起的。两种化合物均抑制水负荷诱导的高眼压，且A - 6、7 - DTN抑制眼压恢复速率，提示后一种化合物部分通过抑制房水生成来降低眼压。舒必利预处理可拮抗A - 6、7 - DTN的眼降压作用，而育亨宾则不能，表明多巴胺受体参与了该反应。这些研究表明多巴胺激动剂可降低眼压，并提示这类药物可能对开角型青光眼的治疗有用。
