Potter D E, Burke J A
Center for Biotechnology, Baylor College of Medicine, Woodlands, Texas.
J Ocul Pharmacol. 1988 Spring;4(1):19-28. doi: 10.1089/jop.1988.4.19.
LY141865 (LY), an ergoline derivative, was investigated for ocular effects in rabbits and monkeys. LY lowered intraocular pressure (IOP) bilaterally in monkeys and rabbits, prevented the bilateral rise in IOP caused by oral waterloading in rabbits and slowed the rate of IOP recovery bilaterally in rabbits. The ocular hypotensive activity of LY in rabbits was inhibited by sympathectomy and pretreatment with sulpiride. Since LY has cardiovascular effects that are centrally mediated, ocular responses may also be mediated, in part, by an action in the CNS.
麦角灵衍生物LY141865（LY）在兔和猴身上进行了眼部效应研究。LY可使猴和兔双侧眼压降低，预防兔口服大量水引起的双侧眼压升高，并减缓兔双侧眼压恢复速率。兔交感神经切除及舒必利预处理可抑制LY的眼降压活性。由于LY具有中枢介导的心血管效应，其眼部反应可能也部分由中枢神经系统的作用介导。
