Perry P J, Alexander B, Prince R A, Dunner F J
J Clin Psychopharmacol. 1984 Oct;4(5):242-6.
A prospective method for recommending lithium carbonate maintenance doses for patients requiring the drug either prophylactically or for acute mania has been previously described. Of 18 patients who required prophylactic lithium levels between 0.40 and 0.89 mEq/liter, the maintenance dose equation achieved the predefined therapeutic range in 15 (83%) cases. Of 20 patients requiring lithium concentrations between 0.90 and 1.30 mEq/liter for the treatment of acute mania, 17 (85%) attained the therapeutic range after receiving the recommended maintenance dose. The authors discuss the factors that limit the usefulness of this prospective dosing protocol.
先前已描述了一种为预防性或治疗急性躁狂症而需要该药物的患者推荐碳酸锂维持剂量的前瞻性方法。在18名需要预防性锂水平在0.40至0.89毫当量/升之间的患者中，维持剂量方程在15例（83%）患者中达到了预定的治疗范围。在20名治疗急性躁狂症需要锂浓度在0.90至1.30毫当量/升之间的患者中，17名（85%）在接受推荐的维持剂量后达到了治疗范围。作者讨论了限制这种前瞻性给药方案实用性的因素。
