一种多价乳糖-N-岩藻五糖III-赖氨酰赖氨酸共轭物可使植入前的小鼠胚胎解压缩，而游离寡糖则无效。
A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.
作者信息
Fenderson B A, Zehavi U, Hakomori S
出版信息
J Exp Med. 1984 Nov 1;160(5):1591-6. doi: 10.1084/jem.160.5.1591.
Abstract
A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.
摘要
一种多价乳糖-N-岩藻五糖（LNFP）III-赖氨酰赖氨酸缀合物被观察到能使植入前的小鼠胚胎解压缩。游离寡糖（LNFP II和III）以及多价LNFP II-赖氨酰赖氨酸或壳三糖-赖氨酰赖氨酸缀合物均未实现解压缩。这些结果表明X抗原决定簇识别在压缩过程中发挥作用，并进一步表明X抗原决定簇的价态可能在调节这一发育过程中起关键作用。
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