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N,N'-二取代的N''-2-(2-喹啉基甲硫基)乙基胍作为潜在抗癌剂的合成

Synthesis of N,N'-disubstituted N''-2-(2-quinolinylmethylthio)ethylguanidines as potential anticancer agents.

作者信息

Foye W O, An S H, Maher T J

出版信息

J Pharm Sci. 1984 Aug;73(8):1168-70. doi: 10.1002/jps.2600730838.

DOI:10.1002/jps.2600730838
PMID:6491929
Abstract

A simple method for obtaining the title compounds was found in the alkaline rearrangement of S-2-aminoethylisothiouronium salts, which were obtained from the condensation of thiourea or substituted thioureas with 2-bromoethylamine hydrobromide. No activity was found for the substituted guanidines against P388 lymphocytic leukemia in mice, or as H2-receptor antagonists.

摘要

通过硫脲或取代硫脲与氢溴酸2-溴乙胺缩合得到的S-2-氨基乙基异硫脲盐的碱性重排反应，发现了一种制备标题化合物的简单方法。所得到的取代胍对小鼠P388淋巴细胞白血病无活性，也无H2受体拮抗剂活性。

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Synthesis of N,N'-disubstituted N''-2-(2-quinolinylmethylthio)ethylguanidines as potential anticancer agents.N,N'-二取代的N''-2-(2-喹啉基甲硫基)乙基胍作为潜在抗癌剂的合成
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