精子提取物（鱼精蛋白）增强实验性结肠肿瘤形成
Experimental colon neoplasia enhanced by extract of sperm (protamine).
作者信息
Phillips R K, Quill D S, Dudley H A
出版信息
J R Soc Med. 1984 Oct;77(10):830-2. doi: 10.1177/014107688407701005.
Abstract
An experimental study of colorectal tumorigenesis in inbred rats given the potent carcinogen dimethylhydrazine has shown that protamine, given before any tumours had developed, significantly enhanced the development of large bowel tumours (100% incidence). Those animals having no adjuvant therapy or who received either heparin or 5-fluorouracil (alone or in combination) had an approximate 50% incidence of such tumours.
摘要
一项针对给予强效致癌物二甲基肼的近交系大鼠结直肠癌发生的实验研究表明，在任何肿瘤出现之前给予鱼精蛋白，可显著增强大肠肿瘤的发生（发生率为100%）。那些未接受辅助治疗或接受肝素或5-氟尿嘧啶（单独或联合使用）的动物，此类肿瘤的发生率约为50%。
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