Frazier M E, Mahlum D D
J Toxicol Environ Health. 1984;13(4-6):531-43. doi: 10.1080/15287398409530518.
A fuel-oil blend (FOB) and its hydrotreated product from the solvent-refined coal (SRC) II process were evaluated for their mutagenic and carcinogenic potential. The FOB was highly active in both cellular assays, as well as in animal (skin-painting) studies. Cell-transforming and mutagenic activities of hydrotreated FOB were consistently found to be lower than for untreated FOB. Finally, while most of the initiating activity (in the animal assay) was lost following hydrotreatment, the data indicate that the hydrotreated FOB still had significant skin-tumor-promoting activity.
对一种来自溶剂精制煤（SRC）II工艺的燃料油混合物（FOB）及其加氢处理产物的致突变性和致癌潜力进行了评估。该FOB在细胞试验以及动物（皮肤涂抹）研究中均具有高活性。一直发现，加氢处理后的FOB的细胞转化和致突变活性低于未处理的FOB。最后，虽然加氢处理后大部分引发活性（在动物试验中）丧失，但数据表明，加氢处理后的FOB仍具有显著的皮肤肿瘤促进活性。
