腺病毒12型非致癌突变体：转化细胞的致癌性以及体内外合成的病毒蛋白
Adenovirus 12 nononcogenic mutants: oncogenicity of transformed cells and viral proteins synthesized in vivo and in vitro.
作者信息
Mak I, Galet H, Mak S
出版信息
J Virol. 1984 Nov;52(2):687-90. doi: 10.1128/JVI.52.2.687-690.1984.
Abstract
Several nononcogenic cyt mutants of adenovirus type 12 induced the same E1A (55,000 [55K] and 25K) and E1B polypeptides (55K, 19K, and 17K) as did the wild-type virus, except that cyt 68 did not induce the E1B 19K protein. Tumorigenicity tests showed cells transformed by cyt 68 to be highly oncogenic in vivo. Therefore, it was concluded that the E1B 19K polypeptide is not necessary for tumor induction but may be involved in the efficiency of transformation.
摘要
12型腺病毒的几种非致癌性细胞突变体诱导产生的E1A（55000道尔顿[55K]和25K）和E1B多肽（55K、19K和17K）与野生型病毒相同，只是细胞突变体68不诱导产生E1B 19K蛋白。致瘤性试验表明，由细胞突变体68转化的细胞在体内具有高度致癌性。因此，得出的结论是，E1B 19K多肽对于肿瘤诱导不是必需的，但可能与转化效率有关。
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