Oyasu R, Iwasaki T, Ozono S
J Urol. 1984 Nov;132(5):1012-5. doi: 10.1016/s0022-5347(17)49989-7.
Repeated intravesical administrations of 0.9 per cent NaCl solution with or without bladder carcinogen N-butyl-N-(3-carboxypropyl)nitrosamine resulted in a high incidence of calculus formation in the urinary bladder. In all such cases, diffuse papillomatosis of the bladder urothelium was observed. "Invasion" of the tunica muscularis and the tunica adventitia by tumor was demonstrated as early as week 9 of the experiment. Morphologically, the lesions could not be distinguished from the bladder tumors induced by an orally administered carcinogen. Evidence was presented to conclude that they represent neoplasms of low malignant potential. The results indicate that bladder tumors may develop in the absence of known exposure to carcinogen provided the urothelium is chronically stimulated. Tumors solely attributable to N-butyl-N-(3-carboxypropyl)nitrosamine treatment did not occur.
反复膀胱内给予0.9%氯化钠溶液，无论是否添加膀胱致癌物N-丁基-N-（3-羧丙基）亚硝胺，均可导致膀胱结石形成的高发生率。在所有这些病例中，均观察到膀胱尿路上皮的弥漫性乳头状瘤病。早在实验第9周就证实肿瘤“侵犯”了肌层和外膜。从形态学上看，这些病变与口服致癌物诱发的膀胱肿瘤无法区分。有证据表明，它们代表低恶性潜能的肿瘤。结果表明，如果尿路上皮受到慢性刺激，在没有已知致癌物暴露的情况下也可能发生膀胱肿瘤。未出现仅归因于N-丁基-N-（3-羧丙基）亚硝胺治疗的肿瘤。
