Miller A L, Habershaw J A, Dhaliwhal H S, Lister T A
Leuk Res. 1984;8(5):905-12. doi: 10.1016/0145-2126(84)90111-5.
A man presented with a short history suggestive of anaemia and thrombocytopenia. Haematological investigations showed him to have an absolute peripheral lymphocytosis and the bone marrow was almost totally replaced by lymphoid blasts. A lymph node biopsy was interpreted as showing immunoblastic lymphoma supervening on chronic lymphocytic leukaemia. Cell surface marker studies performed on cells from peripheral blood and the excised lymph node demonstrated that the lymphocytes and blast cells carried the same surface monoclonal immunoglobulin and expressed OKT1/Leu I positivity. He was treated with a cytotoxic regimen for adult acute lymphoblastic leukaemia but did not respond. This appears to be the first report of a patient with chronic lymphocytic leukaemia who presented at the time of immunoblastic crisis.
一名男性患者，近期出现提示贫血和血小板减少的症状。血液学检查显示其外周血淋巴细胞绝对计数增多，骨髓几乎完全被淋巴母细胞取代。淋巴结活检结果被解释为免疫母细胞淋巴瘤叠加于慢性淋巴细胞白血病之上。对来自外周血和切除淋巴结的细胞进行的细胞表面标志物研究表明，淋巴细胞和母细胞携带相同的表面单克隆免疫球蛋白，并表达OKT1/Leu I阳性。他接受了针对成人急性淋巴细胞白血病的细胞毒性治疗方案，但无反应。这似乎是首例在免疫母细胞危象时出现的慢性淋巴细胞白血病患者的报告。
