两例慢性淋巴细胞白血病急性原始细胞危象患者中出现带有单克隆表面免疫球蛋白的原始细胞
Blast cells with monoclonal surface immunoglobulin in two cases of acute blast crisis supervening on chronic lymphocytic leukaemia.
作者信息
Brouet J C, Preud'Homme J L, Seligmann M, Bernard J
出版信息
Br Med J. 1973 Oct 6;4(5883):23-4. doi: 10.1136/bmj.4.5883.23.
Abstract
Acute blast crisis occurred in two patients with previously well-confirmed chronic lymphocytic leukaemia. The finding by direct immunofluorescence of membrane-bound monoclonal immunoglobulins on the surface of the blast cells showed that they were related to B cells in the same way as the proliferating lymphocytes in most patients with chronic lymphocytic leukaemia. In one patient the surface monoclonal IgM detected on both the lymphocytes and the blast cells had the same rheumatoid antibody activity, supporting the concept that the leukaemic cells found during the acute and chronic phases of the disease originated from the same clone.
摘要
两名先前确诊为慢性淋巴细胞白血病的患者发生了急性原始细胞危象。通过直接免疫荧光法发现原始细胞表面存在膜结合单克隆免疫球蛋白，这表明它们与大多数慢性淋巴细胞白血病患者的增殖淋巴细胞一样，与B细胞相关。在一名患者中，在淋巴细胞和原始细胞上检测到的表面单克隆IgM具有相同的类风湿抗体活性，这支持了疾病急性和慢性阶段发现的白血病细胞起源于同一克隆的概念。
相似文献
1
Blast cells with monoclonal surface immunoglobulin in two cases of acute blast crisis supervening on chronic lymphocytic leukaemia.两例慢性淋巴细胞白血病急性原始细胞危象患者中出现带有单克隆表面免疫球蛋白的原始细胞
Br Med J. 1973 Oct 6;4(5883):23-4. doi: 10.1136/bmj.4.5883.23.
2
Blast crisis supervening on chronic lymphocytic leukaemia. A monoclonal progression of the disease as defined by cell surface markers.
Eur J Haematol. 1987 Oct;39(4):376-82. doi: 10.1111/j.1600-0609.1987.tb00786.x.
3
4
Surface immunoglobulins on lymphocytes in chronic lymphocytic leukaemia and lymphosarcoma.慢性淋巴细胞白血病和淋巴肉瘤中淋巴细胞表面免疫球蛋白
Br J Haematol. 1973 May;24(5):563-9. doi: 10.1111/j.1365-2141.1973.tb01682.x.
5
[Surface immunoglobulins of lymphocytes in chronic lymphocytic leukemia].[慢性淋巴细胞白血病中淋巴细胞的表面免疫球蛋白]
Acta Haematol Pol. 1976;7(1):23-30.
6
7
Chronic lymphocytic leukaemia with subsequent development of multiple myeloma. Evidence of two B-lymphocyte clones and of myeloma-induced suppression of secretion of an M-component and of normal immunoglobulins.慢性淋巴细胞白血病继发多发性骨髓瘤。存在两个B淋巴细胞克隆的证据，以及骨髓瘤诱导的M成分和正常免疫球蛋白分泌受抑制的证据。
Scand J Haematol. 1978 Sep;21(3):256-64.
8
Mitogen-induced switching of immunoglobulin heavy-chain class secretion in chronic B-lymphocytic leukaemia and immunocytoma cell populations.丝裂原诱导的慢性B淋巴细胞白血病和免疫细胞瘤细胞群体中免疫球蛋白重链类别分泌的转换
Scand J Immunol. 1983 Jan;17(1):51-9. doi: 10.1111/j.1365-3083.1983.tb00765.x.
9
Clinical correlations with immunoglobulin levels in chronic lymphatic leukaemia.
Aust N Z J Med. 1972 Nov;2(4):346-50. doi: 10.1111/j.1445-5994.1972.tb03935.x.
引用本文的文献
1
Acute subdural hematoma due to acute myeloid leukemia and B-cell lymphoma.急性髓系白血病和B细胞淋巴瘤所致急性硬膜下血肿
eNeurologicalSci. 2022 Sep 15;29:100425. doi: 10.1016/j.ensci.2022.100425. eCollection 2022 Dec.
2
Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: A rare case report.慢性淋巴细胞白血病快速转化为急性淋巴细胞白血病：一例罕见病例报告。
J Basic Clin Pharm. 2016 Mar;7(2):60-3. doi: 10.4103/0976-0105.177702.
3
Achieving optimal outcomes in chronic lymphocytic leukaemia.在慢性淋巴细胞白血病中实现最佳治疗效果。
Drugs. 2001;61(5):593-611. doi: 10.2165/00003495-200161050-00005.
4
Malignant lymphomas: cell surface markers and advances in classification.恶性淋巴瘤：细胞表面标志物与分类进展
West J Med. 1981 Oct;135(4):276-84.
5
Male hypogonadism.男性性腺功能减退
West J Med. 1976 Jun;124(6):446-75.
6
Morphology of lymphatic cells and of their derived tumours.淋巴细胞及其衍生肿瘤的形态学。
J Clin Pathol. 1978 Nov;31(11):1009-56. doi: 10.1136/jcp.31.11.1009.
7
Malignant lymphomas--a conceptual understanding of morphologic diversity. A review.恶性淋巴瘤——对形态学多样性的概念性理解。综述。
Am J Pathol. 1979 Jan;94(1):105-92.
8
Chronic lymphocytic leukemia.慢性淋巴细胞白血病
West J Med. 1977 Sep;127(3):221-8.
9
Celluar immunoglobulins in human gamma- and alpha-heavy chain diseases.人类γ和α重链病中的细胞免疫球蛋白
Clin Exp Immunol. 1979 Aug;37(2):283-91.
本文引用的文献
1
2
The acute leukemias. Analysis of 322 cases and review of the literature.急性白血病。322例病例分析及文献综述。
Medicine (Baltimore). 1962 Sep;41:163-225.
3
Multiple myeloma and acute myelomonocytic leukemia.多发性骨髓瘤和急性粒单核细胞白血病。
N Engl J Med. 1970 Nov 19;283(21):1121-5. doi: 10.1056/NEJM197011192832101.
4
Stem cell leukaemia in myelomatosis.
Scand J Haematol. 1970;7(3):201-7. doi: 10.1111/j.1600-0609.1970.tb01888.x.
5
Acute leukemia occurring during chronic lymphocytic leukemia.
Blood. 1970 Jan;35(1):7-11.
6
[Membrane monoclonal immunoglobulins in chronic lymphoid leukemia].[慢性淋巴细胞白血病中的膜单克隆免疫球蛋白]
Rev Eur Etud Clin Biol. 1971 Dec;16(10):1025-31.
7
Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases.表面结合免疫球蛋白作为人类淋巴增殖性疾病中的细胞标志物
Blood. 1972 Dec;40(6):777-94.
8
Immunoglobulins on the surface of lymphoid cells in Waldenström's macroglobulinemia.华氏巨球蛋白血症中淋巴样细胞表面的免疫球蛋白
J Clin Invest. 1972 Mar;51(3):701-5. doi: 10.1172/JCI106858.
9
[Acute terminal transformation of chronic lymphatic leukemia].
Sem Hop. 1970 Oct 20;46(42):2678-80.
10
Anti-human immunoglobulin G activity of membrane-bound monoclonal immunoglobulin M in lymphoproliferative disorders.淋巴增生性疾病中膜结合单克隆免疫球蛋白M的抗人免疫球蛋白G活性
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2132-5. doi: 10.1073/pnas.69.8.2132.
Zotero 插件