Morimoto T, Komaki K, Yamamoto H, Umemoto A, Inui K, Nishimoto K, Sonoo H, Harada K, Inoue K
Nihon Geka Gakkai Zasshi. 1984 Aug;85(8):758-62.
In 141 mastectomy specimens, performed for invasive or non-invasive carcinomas, histopathologic study was performed to assess the extent of nipple-areola involvement by the tumor. In this study, patients were excluded when 1) the tumor was located beneath the areola, 2) nipple and/or areola abnormalities were clinically present. Tumor involvement of the nipple and/or areola was found in 44 of 141 specimens (31%), with intraductal growth in 36 (82%) of 44, stromal invasion in 3 (7%) and ductal & stromal invasion in 5 (11%). Analysis of nipple-areolar involvement with consideration of the different variables indicates that it occurred in association with tumor size, tumor-areola distance and histological type. Such information provides clinically relevant guide lines in decision making for limited breast surgery.
在141例因浸润性或非浸润性癌而进行的乳房切除标本中，进行了组织病理学研究以评估肿瘤累及乳头乳晕的范围。在本研究中，若患者出现以下情况则被排除：1）肿瘤位于乳晕下方；2）临床上存在乳头和/或乳晕异常。在141例标本中有44例（31%）发现肿瘤累及乳头和/或乳晕，其中44例中有36例（82%）为导管内生长，3例（7%）为间质浸润，5例（11%）为导管及间质浸润。对乳头乳晕受累情况结合不同变量进行分析表明，其发生与肿瘤大小、肿瘤与乳晕的距离及组织学类型有关。这些信息为有限性乳房手术的决策提供了临床相关的指导原则。
