Gracey M
Nahrung. 1984;28(6-7):659-66. doi: 10.1002/food.19840280630.
The mucosa of the upper small intestine in humans is repeatedly exposed to potentially harmful environmental influences: infective, toxic and antigenic. One of the most significant manifestations of the control over environmental risks is how the upper intestinal milieu is kept relatively sterile and pathogen-free despite constant exposure to a potentially hostile and pathogen-ridden environment. This control is lost in the so-called "Contaminated Small-Bowel Syndrome" when profuse numbers of bacteria contaminate the contents of the upper bowel. This can occur in a vast array of clinical situations ranging from infancy to old age. The consequences of upper intestinal bacterial overgrowth are very diverse. The mechanisms causing diarrhoea and malabsorption in this syndrome illustrate facets of pathophysiology of many inter-relating processes of intestinal digestion and absorption.
感染性、毒性和抗原性影响。对环境风险进行控制的最显著表现之一，是尽管上肠道持续暴露于潜在的敌对且充满病原体的环境中，但上肠道环境如何保持相对无菌且无病原体。当大量细菌污染上肠道内容物时，这种控制在所谓的“污染性小肠综合征”中丧失。这可能发生在从婴儿期到老年期的大量临床情况中。上肠道细菌过度生长的后果非常多样。该综合征中导致腹泻和吸收不良的机制阐明了肠道消化和吸收许多相互关联过程的病理生理学方面。
