Mastropaolo J P, Dacanay R J, Luna B H, Tuck D L, Riley A L
Neurobehav Toxicol Teratol. 1984 May-Jun;6(3):193-9.
The effects of a range of doses of trimethyltin chloride (1.8-7.0 mg/kg, TMT) on responding maintained under a differential-reinforcement-of-low-rate 15-sec schedule of water presentation were examined in rats. TMT produced a large decrease in the percent of reinforced responses and consequently a decrease in the rate of reinforcement. These effects were due primarily to prolonged bursts of nonreinforced responses. In contrast to the gradual dose-related decrease in body weight produced by TMT, responding was disrupted only at the highest dose tested, i.e., 7.0 mg/kg. The results were discussed in terms of the neurotoxic effects of TMT on the limbic system.
研究了一系列剂量的氯化三甲基锡（1.8 - 7.0毫克/千克，TMT）对大鼠在以低速率15秒强化饮水程序维持反应的影响。TMT使强化反应的百分比大幅下降，从而导致强化速率降低。这些影响主要是由于未强化反应的长时间爆发。与TMT导致的体重随剂量逐渐下降相反，反应仅在测试的最高剂量即7.0毫克/千克时受到干扰。根据TMT对边缘系统的神经毒性作用对结果进行了讨论。
