Hochberg F, Toniolo P, Cole P
Neurology. 1984 Nov;34(11):1511-4. doi: 10.1212/wnl.34.11.1511.
This is a case-control study of 160 persons with glioblastoma and 128 of their "best friends" as controls. Subjects came mainly from greater Boston, and data were gathered by questionnaire and telephone interview. Among those who had had a "severe" head injury at age 15 or later, the age-adjusted rate ratio (RR) of glioblastoma was 10.6, p = 0.004. There were six cases and no controls who had seizures for 15 or more years. The related RR is inestimable, but has a p value of 0.03. We could not evaluate whether the latter association implies a direct relationship between the causes of seizures and the causes of glioblastoma, or if it reflects the effect of another factor, such as medications to control the seizures.
这是一项病例对照研究，研究对象为160例胶质母细胞瘤患者及其作为对照的128名“挚友”。研究对象主要来自大波士顿地区，数据通过问卷调查和电话访谈收集。在15岁及以后曾遭受“严重”头部损伤的人群中，胶质母细胞瘤的年龄调整率比（RR）为10.6，p = 0.004。有6例患者癫痫发作15年及以上，而对照组无此情况。相关的RR无法估计，但p值为0.03。我们无法评估后一种关联是意味着癫痫病因与胶质母细胞瘤病因之间存在直接关系，还是反映了另一个因素的影响，比如控制癫痫的药物。
