阿洛西林和羧苄西林对856株临床分离菌的体外活性比较。
Comparison of the in vitro activity of azlocillin and carbenicillin against 856 clinical bacterial isolates.
作者信息
Skar A G, Midtvedt T, Dahl O
出版信息
NIPH Ann. 1984 Jun;7(1):13-9.
Eight hundred and fifty-six strains of more than ten species: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, Escherichia coli, Klebsiella spp, Proteus mirabilis, Proteus vulgaris, Enterobacter spp, Pseudomonas spp and Acinetobacter spp, were tested by the disc diffusion method against azlocillin and carbenicillin. Azlocillin was found to be superior to carbenicillin against Pseudomonas spp, and more than 90% of the tested strains had minimal inhibitory concentration (MIC) values well below the serum levels attainable after recommended doses of azlocillin. Against Enterobacteriaceae and Gram-positive cocci, however, azlocillin seemed to have little to offer.
采用纸片扩散法，对金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌、大肠杆菌、克雷伯菌属、奇异变形杆菌、普通变形杆菌、肠杆菌属、假单胞菌属和不动杆菌属等十多个菌种的856株菌株进行了针对阿洛西林和羧苄西林的测试。结果发现，阿洛西林对假单胞菌属的抗菌效果优于羧苄西林，超过90%的受试菌株的最低抑菌浓度（MIC）值远低于推荐剂量阿洛西林给药后所能达到的血清水平。然而，对于肠杆菌科细菌和革兰氏阳性球菌，阿洛西林似乎并无明显优势。
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