Broekkamp C L, LePichon M, Lloyd K G
Neurosci Lett. 1984 Sep 7;50(1-3):313-8. doi: 10.1016/0304-3940(84)90505-6.
Morphine (10 micrograms/microliter) was injected into different sites within the pontine brainstem in different groups of rats with indwelling guide cannulae. The rats were tested for the persistence of abnormal postures as a measure for the degree of akinesia. Local morphine was most effective in inducing akinesia at a site identical or close to the nucleus raphe pontis. Midline injections were effective in contrast to bilateral injections. Fenfluramine, a serotonin releaser, strongly potentiated morphine akinesia.
在不同组留置引导套管的大鼠中，将吗啡（10微克/微升）注射到脑桥脑干内的不同部位。测试大鼠异常姿势的持续时间，以此作为运动不能程度的指标。局部注射吗啡在中缝脑桥核相同或附近部位诱导运动不能最为有效。与双侧注射相比，中线注射有效。5-羟色胺释放剂芬氟拉明强烈增强吗啡诱导的运动不能。
