福尔马林试验：灵长类动物的一种紧张性疼痛模型。

The formalin test: a tonic pain model in the primate.

作者信息

Alreja Meenakshi, Mutalik Pradeep, Nayar Usha, Manchanda S K

机构信息

Department of Physiology, All-India Institute of Medical Sciences, New Delhi 110029 India.

出版信息

Pain. 1984 Sep;20(1):97-105. doi: 10.1016/0304-3959(84)90815-7.

DOI:10.1016/0304-3959(84)90815-7

PMID:6493793

Abstract

The formalin test has been used in monkeys for assessing pain. After formalin injection in the palmar surface of the hand just proximal to the base of the fingers, the monkey's responses are rated for 1 h according to objective behavioral criteria. The present 'tonic' pain model has a fair degree of objectivity, validity, reproducibility and quantifiability. The analgesic effects of morphine and pethidine have been evaluated.

摘要

福尔马林试验已用于猴子以评估疼痛。在手指基部近端的手掌表面注射福尔马林后，根据客观行为标准对猴子的反应进行1小时的评分。目前的“持续性”疼痛模型具有相当程度的客观性、有效性、可重复性和可量化性。已评估了吗啡和哌替啶的镇痛效果。