Laptook A R, Rosenfeld C R
Pediatr Pharmacol (New York). 1984;4(3):161-5.
Ventilator care in premature infants with hyaline membrane disease (HMD) may be complicated by episodes of irritability and "fighting" the respirator, resulting in significant hypoxemia. Neuromuscular blockade with pharmacologic agents such as pancuronium bromide is frequently used to manage this problem [Crone and Favorito, 1980]. This therapy results in the loss of important clinical signs, such as alterations in muscle tone and spontaneous movements, which are important in monitoring the critically ill newborn. As a result of these considerations, we occasionally have utilized the sedative-hypnotic effects of chloral hydrate to achieve adequate ventilation and oxygenation in these infants. We report, however, a case of a preterm infant who developed severe chloral hydrate toxicity after its administration as an adjunct to the treatment of HMD.
患有透明膜病（HMD）的早产儿进行呼吸机护理时，可能会因烦躁不安和“抗拒”呼吸机而变得复杂，从而导致严重的低氧血症。经常使用诸如潘库溴铵等药物进行神经肌肉阻滞来处理这个问题[克朗和法沃里托，1980年]。这种疗法会导致重要临床体征的丧失，如肌张力和自主运动的改变，而这些体征对于监测危重新生儿很重要。出于这些考虑，我们偶尔会利用水合氯醛的镇静催眠作用，以使这些婴儿获得足够的通气和氧合。然而，我们报告了一例早产儿在将水合氯醛作为HMD治疗辅助药物使用后发生严重水合氯醛中毒的病例。
