Mayers D J, Hindmarsh K W, Gorecki D K, Sankaran K
Perinatal Research Laboratory, College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Dev Pharmacol Ther. 1992;19(2-3):141-6. doi: 10.1159/000457475.
Although the metabolism and pharmacokinetics of chloral hydrate (CH) have been reported, there have been no attempts to correlate CH or its metabolite, trichloroethanol (TCE) with the sedative or hypnotic effects. In order to determine whether plasma concentrations of CH or TCE reflect the sedative/hypnotic effects, a sedation/agitation scale was developed. Based on the results of the present study, the sedative/hypnotic effects of TCE cannot be ruled out completely. However, in the neonate, the parent drug CH seems to have a more important role than has been previously suggested from human research.
虽然水合氯醛（CH）的代谢和药代动力学已有报道，但尚未有人尝试将CH或其代谢物三氯乙醇（TCE）与镇静或催眠作用相关联。为了确定CH或TCE的血浆浓度是否反映镇静/催眠作用，制定了一个镇静/躁动量表。根据本研究结果，不能完全排除TCE的镇静/催眠作用。然而，在新生儿中，母体药物CH似乎比之前人体研究表明的作用更为重要。
