Philips J B, Braune K, Ravis W, Cassady G, Dillon H
Pediatr Pharmacol (New York). 1984;4(3):193-7.
We studied the disposition of two 100 mg/kg doses of cefoperazone given intravenously 12 hr apart in ten newborn infants. Peak levels were a mean 352 +/- SD 75 and 371 +/- 68 micrograms/ml immediately after the first and second dose, respectively, with corresponding troughs of 60 +/- 10 and 76 +/- 28 mcg/ml 12 hr later. Mean half-life was 6.5 +/- 0.9 hr and decreased with increasing gestational age and birthweight. Steady-state volume of distribution averaged 410 +/- 40 ml/kg and total clearance 0.78 +/- 0.13 ml/min X kg and neither varied with gestational age nor birthweight. No untoward physical or laboratory effects were noted. Additional studies including postnatal age effects on kinetics, efficacy, and cerebrospinal fluid penetrance are necessary prior to widespread use of this potentially valuable antibiotic in newborn infants.
我们研究了10名新生儿每隔12小时静脉注射两次100mg/kg头孢哌酮的药物处置情况。首次和第二次给药后即刻的峰值水平分别平均为352±标准差75和371±68微克/毫升，12小时后的相应谷值分别为60±10和76±28微克/毫升。平均半衰期为6.5±0.9小时，且随着胎龄和出生体重的增加而缩短。稳态分布容积平均为410±40毫升/千克，总清除率为0.78±0.13毫升/分钟·千克，两者均不随胎龄和出生体重而变化。未观察到不良的身体或实验室效应。在新生儿广泛使用这种可能有价值的抗生素之前，有必要进行包括出生后年龄对动力学、疗效和脑脊液通透性影响的进一步研究。
