Mariño E L, Fernández Lastra C, Gonzalez Alonso I, Dominguez-Gil A
Arzneimittelforschung. 1987 Mar;37(3):345-9.
The pharmacokinetics of cefoperazone were studied after i.v. administration of a single 30 mg/kg dose in a total of 40 New Zealand rabbits. Determination of the plasma levels of the drug revealed a slow elimination half-life of 0.48 h. The disappearance half-life of cefoperazone in interstitial tissue fluid shows a mean value of 1.9 h, being statistically higher than the value found for the half-life of the slow phase of elimination from the systemic circulation. 12 h after i.v. administration, 32.1% of the drug was seen to be excreted by the kidney and a further 15.2% in bile. The urinary excretion constant had a mean value of 0.29 h-1, whereas that of biliary excretion was 0.12 h-1.
在40只新西兰兔静脉注射单次30mg/kg剂量后，对头孢哌酮的药代动力学进行了研究。药物血浆水平的测定显示消除半衰期缓慢，为0.48小时。头孢哌酮在组织间液中的消失半衰期平均值为1.9小时，在统计学上高于从体循环中消除的慢相半衰期值。静脉注射12小时后，发现32.1%的药物经肾脏排泄，另有15.2%经胆汁排泄。尿排泄常数的平均值为0.29 h-1，而胆汁排泄常数为0.12 h-1。
