Verleye M, Bernet F
Pharmacol Biochem Behav. 1984 Sep;21(3):357-63. doi: 10.1016/s0091-3057(84)80095-7.
The effects of bilateral lesions of the dorsal noradrenergic bundle (DB) or of the locus coeruleus (LC) on the rat's behavior in different anxiogenic behavioral situations have been studied. The DB rats defecate less but ambulate more than shams in the open-field (O.F.); these data suggest a decrease in the reactivity of these animals to novelty. Furthermore, the LC rats have a behavior identical to that of shams in the O.F. We note moreover that the DB rats do not habituate to a novel stimulus. During the Henderson test, the behavioral inhibition of all lesioned animals seems to be less important than that of shams. These results are discussed in relation to existing hypotheses of the DB function. The lesions of DB induce a decrease in the noradrenaline (NA) cortical level and in the catecholamines level in hypothalamus. The lesions of LC produce 30% loss of forebrain NA. These results reveal a discrepancy between the effects induced by the lesioning of DB fibers and those produced by lesions of LC, which originate in the DB. The presence of non-noradrenergic elements, fibers of passage, which do not travel with the DB fibers or terminals in the LC region may be elements for interpretation.
研究了去甲肾上腺素能背侧束（DB）或蓝斑（LC）双侧损伤对大鼠在不同致焦虑行为情境中行为的影响。在旷场实验（O.F.）中，DB损伤大鼠的排便次数比假手术组少，但活动量比假手术组多；这些数据表明这些动物对新奇事物的反应性降低。此外，LC损伤大鼠在旷场实验中的行为与假手术组相同。我们还注意到DB损伤大鼠对新刺激不产生习惯化。在亨德森试验中，所有损伤动物的行为抑制似乎比假手术组弱。结合现有的关于DB功能的假说对这些结果进行了讨论。DB损伤导致皮质去甲肾上腺素（NA）水平以及下丘脑儿茶酚胺水平降低。LC损伤导致前脑NA损失30%。这些结果揭示了DB纤维损伤所诱导的效应与起源于DB的LC损伤所产生的效应之间存在差异。在LC区域存在不与DB纤维或终末一起走行的非去甲肾上腺素能成分、过路纤维，这可能是解释该差异的因素。
