Chen D J, Strniste G F, Tokita N
Radiat Res. 1984 Nov;100(2):321-7.
Cell inactivation and induced mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus have been measured in cultured human fibroblasts (GM10) exposed to alpha particles from 238Pu (LET at the cell surface was 100 keV/microns) and 250 kVp X rays. The survival curves resulting from exposure to alpha particles are exponential. The mean lethal dose, D0, is approximately 1.3 Gy for X rays and 0.25 Gy for alpha particles. As a function of radiation dose, mutation induction at the HGPRT locus was linear for alpha particles whereas the X-ray-induced mutation data were better fitted by a quadratic function. When mutation frequencies were plotted against the log of survival, mutation frequency at a given survival level was greater in cells exposed to alpha particles than to X rays.
在暴露于来自238Pu的α粒子（细胞表面的传能线密度为100 keV/μm）和250 kVp X射线的培养人成纤维细胞（GM10）中，已测量了次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶（HGPRT）位点的细胞失活和诱导突变频率。暴露于α粒子产生的存活曲线是指数型的。平均致死剂量D0，对于X射线约为1.3 Gy，对于α粒子约为0.25 Gy。作为辐射剂量的函数，HGPRT位点的突变诱导对于α粒子是线性的，而X射线诱导的突变数据用二次函数拟合更好。当将突变频率与存活对数作图时，在给定存活水平下，暴露于α粒子的细胞中的突变频率高于暴露于X射线的细胞。
