Nagy G, Takács L, Halász B
Regul Pept. 1984 Jul;8(4):321-6. doi: 10.1016/0167-0115(84)90042-9.
The effect of an enkephalin analogue, (D-Met2,Pro5)enkephalinamide (EKNH2) on prolactin (PRL) secretion of lactating rats continuously suckled or separated from their pups was investigated. In rats together with their pups 0.5 mg/kg EKNH2 caused a dramatic decrease, 0.25 mg/kg a mild and short-lasting reduction in plasma PRL levels. In contrast, in lactating rats separated for 4 h from their pups 0.5 mg/kg of the drug induced a slight and 1.0 mg/kg a considerable increase in plasma PRL levels. The data indicate that in lactating rats depending on the circumstances the enkephalin analogue causes opposite effects on PRL secretion.
研究了脑啡肽类似物（D-蛋氨酸²，脯氨酸⁵）脑啡肽酰胺（EKNH₂）对持续哺乳或与幼崽分离的泌乳大鼠催乳素（PRL）分泌的影响。在与幼崽在一起的大鼠中，0.5mg/kg的EKNH₂导致血浆PRL水平急剧下降，0.25mg/kg则导致轻度且持续时间短的下降。相反，在与幼崽分离4小时的泌乳大鼠中，0.5mg/kg的该药物引起血浆PRL水平略有升高，而1.0mg/kg则使其显著升高。数据表明，在泌乳大鼠中，根据具体情况，脑啡肽类似物对PRL分泌会产生相反的影响。
