蛙皮素诱导的心脏副交感神经支配刺激。

Bombesin-induced stimulation of cardiac parasympathetic innervation.

作者信息

Fisher L A, Brown M R

出版信息

Regul Pept. 1984 Jul;8(4):335-43. doi: 10.1016/0167-0115(84)90044-2.

Abstract

The central nervous system effects of bombesin on cardiovascular function were examined in conscious, freely-moving rats. Intracerebroventricular administration of bombesin elevated mean arterial pressure, reduced heart rate and inhibited cold-induced tachycardia. Adrenalectomy prevented bombesin-induced elevations of mean arterial pressure. In contrast, bombesin-induced bradycardia was neither adrenal-dependent nor a baroreceptor-mediated reflex response to increased arterial pressure. Systemic atropine methyl nitrate treatment attenuated bombesin-induced bradycardia, suggesting that bombesin acts within the central nervous system to stimulate cardiac vagal activity.

摘要

在清醒、自由活动的大鼠中研究了蛙皮素对心血管功能的中枢神经系统效应。脑室内注射蛙皮素可升高平均动脉压、降低心率并抑制冷诱导的心动过速。肾上腺切除术可预防蛙皮素引起的平均动脉压升高。相比之下，蛙皮素引起的心动过缓既不依赖肾上腺，也不是对动脉压升高的压力感受器介导的反射反应。全身给予硝酸甲基阿托品治疗可减弱蛙皮素引起的心动过缓，提示蛙皮素在中枢神经系统内发挥作用以刺激心脏迷走神经活动。