Bellia V, Cibella F, Coppola P, Greco V, Insalaco G, Milone F, Oddo S, Peralta G
Respiration. 1984;46(3):328-33. doi: 10.1159/000194707.
The prognostic relevance of an enhanced variability of peak expiratory flow rate (PEFR) throughout the day was evaluated in asthmatics in remission: it was expressed as the coefficient of variation (CV) of values recorded 4 times daily for 2 weeks. Outcome at 3, 6, and 12 months was assessed in 2 groups of 16 patients each, differing because of a CV respectively higher (group A) and lower (group B) than 8%. A significantly higher frequency of abnormal PEFR values during the subsequent 3 months was recorded in patients of group A, and found as correlated to the magnitude of CV; in the same group a significantly worse clinical status--scored on the basis of response to treatment--was pointed out. Therefore, a high CV of PEFR may be assumed as a reliable indicator of the risk of exacerbation--not otherwise predictable--both in a short and a longer term; on this basis home monitoring of PEFR may be recommended as a useful tool in the evaluation of all the cases of asthma in remission.
对处于缓解期的哮喘患者，评估了全天呼气峰值流速（PEFR）变异性增强的预后相关性：其以连续2周每天记录4次的值的变异系数（CV）表示。对两组各16例患者进行了3、6和12个月的预后评估，两组的差异在于CV分别高于（A组）和低于（B组）8%。A组患者在随后3个月内记录到的异常PEFR值频率显著更高，且发现与CV大小相关；在同一组中，指出基于治疗反应评分的临床状态显著更差。因此，PEFR的高CV可被视为短期和长期内哮喘加重风险（否则无法预测）的可靠指标；在此基础上，可推荐在家中监测PEFR，作为评估所有缓解期哮喘病例的有用工具。
