Granieri E, Paolino E, Tola M R, Carreras M, Monetti V C, De Bastiani P, Pinna L, Merlin I, Altobelli A, Finotti L
Riv Neurol. 1984 Jul-Aug;54(4):245-64.
Incidence and prevalence investigations on childhood epilepsy, throughout the world, have suggested wide variations in the frequency of convulsive disorders. Also the few studies presently available from Italy mirror such a disagreement. However, these studies cannot be completely comparable owing to a marked methodological dishomogeneity in definition of epilepsy, classification of seizures, and ascertainment, collection, and selection of the cases. Therefore, to verify the true frequency of childhood epilepsy in our country, we performed an epidemiologic study of convulsive disorders in 0-14 age children of the U.S.L. 34 (Copparo, Northern Italy). The prevalence per 1.000 children on October 24, 1981 was 6.14 (6.4 if standardized to the Italian population). The average annual incidence for the period 1964 through 1980 was 95.1 per 100,000 (98.9 if standardized). These results, similar to those found in other Western countries, support the view that the frequency of childhood epilepsy in Italy as a whole is higher than that indicated by previously published Italian studies and furthermore suggest that epilepsy is evenly distributed in Europe and the United States. Antecedents which could be considered potential causes of seizures were found in 40.2% and 43.6% of the incidence and prevalence cases, respectively; for both groups, perinatal brain injuries were the most frequent event. These results point out the urgency of planning precautionary measures in Italy to improve prenatal and perinatal medical care.
全球范围内针对儿童癫痫的发病率和患病率调查表明,惊厥性疾病的发病频率差异很大。目前来自意大利的少数研究也反映出这种不一致性。然而,由于在癫痫定义、发作分类以及病例的确定、收集和选择方面存在明显的方法学异质性,这些研究无法完全可比。因此,为了核实我国儿童癫痫的实际发病频率,我们对34号地方卫生单位(意大利北部科帕罗)0至14岁儿童的惊厥性疾病进行了一项流行病学研究。1981年10月24日每1000名儿童中的患病率为6.14(若按意大利人口标准化则为6.4)。1964年至1980年期间的年均发病率为每10万人95.1例(若标准化则为98.9例)。这些结果与其他西方国家的结果相似,支持了这样一种观点,即意大利整体儿童癫痫的发病频率高于此前意大利研究表明的频率,并且进一步表明癫痫在欧洲和美国分布均匀。在发病率和患病率病例中,分别有40.2%和43.6%发现了可被视为癫痫发作潜在病因的既往史;对于这两组而言,围产期脑损伤是最常见的情况。这些结果指出了意大利规划预防措施以改善产前和围产期医疗保健的紧迫性。