Barsoum N J, Gough A W, Sturgess J M, de la Iglesia F A
Toxicol Pathol. 1984;12(1):26-38. doi: 10.1177/019262338401200104.
A morphologic study of spontaneous proliferative lesions of the mammary gland was based on histologic examination of mammary glands from 1020 male and 1145 female albino Wistar rats aged 6 to 110 weeks. Three hundred and seventy-five mammary tumors representing an overall incidence of 33% were identified in the female groups, while the males had a total of five tumors which represented an incidence of 0.5%. Histologically, the most common types of tumors in females were: fibroadenoma (236), carcinoma (85), adenoma (40) and fibroma (8). Duct papilloma (1), lobular carcinoma (1), fibrosarcoma (1) and phyllodes tumor (1), were rare and constituted less than 2% of mammary neoplastic lesions. Mammary tumors were rare before one year of age, but increased with age thereafter. Nine percent of female rats studied also had proliferative non-neoplastic lesions that showed a mixture of benign ductular and/or lobular hyperplasia. One hundred and six of these lesions were identified, representing 22% of all grossly palpable nodules, thus stressing the importance of histologic examination of all gross mammary nodules for tumor evaluation.
一项关于乳腺自发性增生性病变的形态学研究，基于对1020只6至110周龄雄性和1145只雌性白化Wistar大鼠乳腺的组织学检查。在雌性组中，共识别出375个乳腺肿瘤，总发病率为33%，而雄性组共有5个肿瘤，发病率为0.5%。组织学上，雌性最常见的肿瘤类型为：纤维腺瘤（236个）、癌（85个）、腺瘤（40个）和纤维瘤（8个）。导管乳头状瘤（1个）、小叶癌（1个）、纤维肉瘤（1个）和叶状肿瘤（1个）较为罕见，占乳腺肿瘤性病变的比例不到2%。乳腺肿瘤在1岁前很少见，但此后随年龄增长而增加。所研究的雌性大鼠中有9%还患有增生性非肿瘤性病变，表现为良性导管和/或小叶增生混合。共识别出106个此类病变，占所有可触及肿块的22%，因此强调了对所有乳腺肿块进行组织学检查以评估肿瘤的重要性。
