人抗金黄色葡萄球菌α毒素抗体的亚类分布：IgG1、IgA1、IgG4转换模式的提示
Subclass distribution of human anti-Staphylococcus aureus alpha toxin antibodies: suggestion of an IgG1, IgA1, IgG4 switch pattern.
作者信息
Hammarström L, Persson M A, Smith C I
出版信息
Scand J Immunol. 1984 Sep;20(3):247-50. doi: 10.1111/j.1365-3083.1984.tb00998.x.
Abstract
The subclass distribution of antibodies against alpha toxin from Staphylococcus aureus in man was investigated. Antibodies were restricted to IgG1, IgA1, and IgG4 and appeared to develop sequentially. These data suggest a distinct pattern of class and subclass switches in response to protein antigens. However, studies in immunodeficient (class- or subclass-deficient) donors show that the proposed patterns is not obligatory.
摘要
对人体中抗金黄色葡萄球菌α毒素抗体的亚类分布进行了研究。抗体仅限于IgG1、IgA1和IgG4，且似乎是依次产生的。这些数据表明，针对蛋白质抗原会出现一种独特的类别和亚类转换模式。然而，对免疫缺陷（类别或亚类缺陷）供体的研究表明，所提出的模式并非必然。
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